姊呴夯鍚曠編闆€佸笀鍏嶈垂瑙傜湅-凯时登录

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姊呴夯鍚曠編闆€佸笀鍏嶈垂瑙傜湅
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[9]alexion'sfcrninhibitortakesa2-prongedapproachtotacklingautoimmunediseases.retrieveddecember24,2019,fromhttps://www.fiercebiotech.com/research/how-alexion-s-fcrn-inhibitor-could-treat-autoimmune-diseases-2-ways

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3.2019骞村鎵т笟鑽笀鏉ヨ锛屽彲鑳芥槸涓€涓垎姘村箔銆傚ぎ瑙?.15鏇濆厜鎵т笟鑽笀鎸傝瘉涔辫薄涔嬪悗锛屽浗瀹惰嵂鐩戝眬寮€灞曚笓椤硅鍔紝涓ユ煡闆跺敭浼佷笟鎵т笟鑽笀鎸傝瘉琛屻€傞殢鍚庯紝涓€鎵规寕璇佽嵂甯堣娓呯悊锛岃嵂搴楀彈澶勭綒銆傛褰撳ぇ瀹朵互涓烘墽涓氳嵂甯堝皢鏇村姞鍊奸挶鐨勬椂鍊欙紝鏀跨瓥瀹e竷鎵т笟鑽笀鍙互澶氱偣鎵т笟浜嗐€傚啀鍔犱笂鑽搧杩為攣浼佷笟鏂借缁熶竴娉ㄥ唽鎵т笟鑽笀锛岃繛閿侀棬搴楄礋璐d汉鍙互涓嶅啀鐢辨墽涓氳嵂甯堟媴浠伙紝濡傛鑰屾潵锛屾墽涓氳嵂甯堢煭缂洪棶棰樺緱鍒颁簡缂撹в锛屼絾鏄叾鍦颁綅鍙堟湁鐐瑰按灏簡銆?

4.澶╁+鍔涚殑鑺嶉夯姝㈢棄棰楃矑(鏇剧敤鍚嶏細姝㈠姩棰楃矑)閫傚簲鐥囦负灏忓効鎶藉姩绉借鐥囷紝鍔熻兘涓绘不涓哄钩鑲濈唲椋庯紝娓呯伀璞佺棸锛屽畞蹇冨畨绁烇紱鐢ㄤ簬鑲濅孩椋庡姩銆佺棸鐏唴鎵版墍鑷寸殑鎶藉姩鐥囷紝鐥囪闈㈤儴銆佸ご棰堛€佸洓鑲㈡垨韬共閮ㄤ綅鑲岃倝涓嶈嚜涓荤殑鎶藉姩浼存湁鍠夐儴鐨勫紓甯稿彂澹般€佺儲韬佹槗鎬掋€佸彛骞茶垖绾€佺潯鐪犱笉瀹夌瓑鐥囥€傝浜у搧浜?018骞?鏈堣鎴愬姛绾冲叆浼樺厛瀹¤瘎锛岀悊鐢变负鍏锋湁鏄庢樉娌荤枟浼樺娍鍒涙柊鑽€佸効绔ョ敤鑽搧銆?018骞翠腑鍥藉叕绔嬪尰鐤楁満鏋勭粓绔腑鎴愯嵂鍎跨鎯婇鑽競鍦鸿妯″凡杈?.4浜垮厓锛屾柊鑽笂甯傚悗娼滃姏鏈夊緟楠岃瘉銆?

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1.dhvi涓讳换銆佸叡鍚屼綔鑰匓artonf.haynes鍗氬+璇达細鈥滄垜浠病鏈塇iv鐤嫍鐨勫師鍥犳槸鍏嶇柅绯荤粺涓嶆兂浜х敓涓拰鐥呮瘨鎵€闇€鐨勯偅绉嶆姉浣撱€傝繖椤圭爺绌舵槸姒傚康璇佹槑锛屾垜浠彲浠ヨ璁″厤鐤郴缁熸潵鍒涢€犲彲浠ュ埗閫犳纭姉浣撶殑鐜銆傗€滺iv鐤嫍闅句互寮€鍙戜竴涓棶棰樺湪浜庡厤鐤郴缁燂紝瀹冧細灏嗘煇浜涘箍娉涗腑鍜屾姉浣擄紙bnabs锛夎瘑鍒负鍗遍櫓骞跺叧闂叾鐢熶骇锛涘彟涓€涓棶棰樻槸涓拰鎶椾綋闇€瑕佺綍瑙佺殑鍩哄洜缁勬垚鍙樺寲锛岃€岃繖绉嶅彉鍖栧湪鍏抽敭鐨凚缁嗚優澶氭牱鍖栬繃绋嬩腑寰堝皯鍙戠敓銆傚湪杩欓」鐮旂┒涓紝鐮旂┒浜哄憳杩借釜浜嗙浉鍏崇殑绐佸彉锛岀劧鍚庤璁′簡涓€绉岺iv铔嬬櫧锛岄澏鍚戠梾姣掕鑶滅殑v3鑱氱硸鍖哄煙锛岃兘澶熶紭鍏堜笌鍏锋湁涓嶅お鍙兘浣嗗繀瑕佺殑绐佸彉鐨勬姉浣撶粨鍚堛€傚埄鐢ㄨ〃杈句汉涓拰鎶椾綋鍓嶄綋鐨勫皬榧犳ā鍨嬶紝鐮旂┒浜哄憳璇佹槑浜嗗畠浠殑鍏嶇柅鍘熺‘瀹炲彲浠ヨ浣緽缁嗚優璋辩郴鍙戠敓涓嶅彲鑳界殑绐佸彉锛屼粠鑰屼骇鐢熷箍娉涗腑鍜屾姉浣撱€傚厠鏈嶄綋缁嗚優绐佸彉鐨勯殰纰嶏紝淇冭繘骞挎硾涓拰hiv-1鎶椾綋(bnab)鐨勫紑鍙戙€?

2.鍗忚鍐呭鏄剧ず锛屼笁鍦拌寤烘垚鑽搧銆佸尰鐤楀櫒姊般€佸寲濡嗗搧鐩戠闀挎晥鍗忎綔鏈哄埗锛屽湪缁熶竴鐩戠鏍囧噯銆佸崗鍚岀洃绠′笌鍙戝睍銆佹浠舵煡鍔炶仈鍔ㄣ€佹楠屾娴嬨€佷俊鎭叡浜€佸簲鎬ヨ仈鍔ㄣ€侀噸澶ф椿鍔ㄤ緵搴斾繚闅滅瓑鏂归潰寮€灞曞叏闈㈠崗浣溿€?

3.鍏ㄥ浗鑱斿姩锛屼环鏍煎悓姝?

4.[2]5g灏嗕负鍖荤枟棰嗗煙甯︽潵涓€鍦洪瑕嗘€ч潻鍛絉etrieveddec25,2019

5.[1]kakiuchi,n.,yoshida,k.,uchino,m.etal.frequentmutationsthatconvergeonthenfkbizpathwayinulcerativecolitis.nature(2019)doi:10.1038/s41586-019-1856-1

灞曞紑鍏ㄩ儴鏀惰捣

姊呴夯鍚曠編闆€佸笀鍏嶈垂瑙傜湅